purine base - Gout vs Pseudogout
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Gout vs Pseudogout

Sometimes, even if a person lives a healthy lifestyle, abstains from alcohol or drinks it modestly, they can experience a condition that mirrors gout, but is in actuality, a different arthritic condition altogether known as pseudogout. To help you understand the differences between these two, the following is a breakdown of the causes, symptoms and treatments for each condition.


A build up of uric acid that develops into gout can result from:


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 Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Micronutra uses a 30 day independent clinical study as support for its effectiveness. The study claims that people who took two pills, three times a day reported positive results 97.7 % of the time. 94.2% reported that their pain was completely gone. While these are impressive numbers, it is important to note that only 36 people took part in this study. This is by no means an exhaustive research into the benefits and possible side effects of Uricinex. More should be done to validate the claims made about this product.

When choosing your low purine foods, you can have some medium purine rated foods with them about once a day if it does not bother you. Those would include some meats like beef, pork, and possibly chicken. Some seafood choices are relatively safe as well. You should experiment to find what bothers you and what works out well. As long as you work at limiting the purines, you are going to feel much better each day. You might want to have lobster bisque on occasion, as long as you limit your portions, and don't have any other medium purine foods for the rest of the day.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

When looking for low purine foods for your diet, you can find a great variety of things you can have that won't cause any issues with your gout. If you love thick soups, you can have them as long as they are made with low fat milk. Cheese and milk are fine, but again, they should be low in fat. You can also enjoy things like gelatin and a great variety of fruits and fruit juices. Most sweets are just fine, but remember to watch the calories if you are attempting to get your weight down. You can also enjoy things like pasta, and peanut butter is okay for a treat.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Get more information about uricinex.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Looking for some inspiration? The Gout Haters Cookbooks series by Jodi Schneiter are just what you need. Jodi has written three cookbooks that focus on creating delicious meals suitable for all the family that fit in with a low purine diet. Click on the link below for more information:

You may have a hard time finding new foods to eat at first, but after a while you will get used to reading labels and figuring out what works for you and what does not. Any special diet requires a little thought and work, and the low purine foods diet is no exception. After a while though, reading and deciphering items in the store by reading through the ingredients list will become second nature, and you will become accustomed to knowing how to build your own menu with little thought. Feeling better should be all the motivation you need.

Uricinex boasts an all natural composition with no side effects. From a partial list of ingredients on the company's website, the main ingredients are derived from Yucca (a plant), Artichokes, Turmeric (a member of the ginger family), and Sylmarin (Milk Thistle). These ingredients are indeed natural. However the complete list of ingredients is not available for review. As for the side effects, research into similar products shows that a very small percentage of users (one half of 1%) have minor upset stomach symptoms. They are told to take the supplements with a meal in order to alleviate this problem. Again, this has not been reported for Uricinex, but for similar products on the market. The number of affected people is so small, and not directly attributed to Uricinex use, that we can believe the claim.

 
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People Said About Goutezol Gout Treatment
"My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY
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So how does Uricinex stack up against its own claims? According to numerous testimonials, Uricinex does provide relief, sometimes within 72 hours. This pain relief appears to be caused by liquefying the crystallized uric acid that has formed in the joints. This is the cause of pain for gout sufferers. This liquid uric acid is then able to be expelled through urination. So on this count, Uricinex does appear to be legitimate.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

This quick review has outlined a few of the key points to look for when considering Uricinex as a supplement for gout pain relief. Most of its claims appear to be legitimate and the product seems to do what it claims.

Gout Gout is a form of arthritis that occurs suddenly, usually affecting the big toe, and causes severe painful attacks, tenderness and redness in the affected joint. An attack can last days or weeks. Gout is caused by a build up of uric acid which turns into uric acid crystals that are deposited into the joints causing them to become inflamed. The first attack of gout often occurs late at night.

There are some general directions for a low purine diet, but always listen to your doctor's advice in addition to this information. A low purine diet is going to contain almost fifty percent carbohydrates each day, and no more than thirty percent of the diet each day should be made up of fats. The rest should be healthy and lower purine protein sources. Drinks that are normally not allowed on many special diets are actually encouraged. These include soda and coffee. The reason being as that they act as directics, helping your body to flush out the excess uric acid. It's important to drink plenty of water as well to keep your body well hydrated. Alcohol, however, in most forms is not something you should be drinking.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

Uricinex claims to reduce, and sometimes completely eliminate pain and swelling caused by gout. It does this thanks to a proprietary blend that reduces the level of uric acid. Micronutra, the makers of Uricinex, claims that this is all achieved naturally, without the side effects of prescription drugs. In addition, this supplement touts a high level of success, shown in an independent clinical study.

Sufferers from gout, a debilitating and painful condition, often take several prescription medicines to combat this disease. These medications often leave patients with side effects that include impaired liver functions. Many of those afflicted by gout turn to natural supplements to replace/enhance their prescription treatments. Uricinex is one of the most popular of these natural supplements.

Gout Haters Cookbook - The Low Purine Diet

Under normal circumstances, the purines you find in many foods are broken down into uric acid, and the body gets rid of it without any problems. However, for someone with gout, getting rid of this uric acid is problematic, and the result is painful crystals forming in the joints - leading to gout pain. When this happens, there are medications that can help with the pain, but one of the best things a person can do it to is to find low purine foods and make them a major part of their diet. This can offer much-needed relief for most.

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.


 
 
     
 
 





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